A Comparative Evaluation of Antioxidant Activity of Extract and Essential Oil of Origanum onites L. In Vivo

In the present study, effects of Origanum onites L. extract and essential oil O. on antioxidant status liver brain mice were investigated. Due to certain disadvantages oils, such as poor solubility, high volatility sensitivity UV light heat, formulation liposomes with Oregano essentials (OE) was optimized used in this study. The results demonstrated that best composition lipid carriers OE conducted terms polydispersity index (PDI), mean particle size encapsulation efficiency (EE). For further study LE4 used, which contained Lipoid S100 at 45 mg, S75 mg 90 EO. administration for 21 days significantly decreased glutathione (GSH) level livers brains well malondialdehyde (MDA) concentration livers. mice, MDA increased after consumption. Whereas GSH mouse liver, there an (p > 0.05) compared control group. It found both onites. ethanolic plant material affect mice.